The ground for use of chemotherapy for malignant tumors is the theoretical possibility of selectively inhibiting the growth of a malignant cell without significantly damaging the healthy tissues and organs of the patient. However, not all the locations and forms of a malignant tumor are equally sensitive to chemotherapy drugs.
Rational chemotherapy involves the use of different regimens depending on the treatment task. The treatment regimen can be intense, causing significant side effects, moderately toxic or simply non-toxic. Repeat courses are considered mandatory. The intervals between the courses are determined by the task of treatment and by the characteristic of the side effects of the drugs. The therapeutic effect of antitumor drugs is evaluated after each course of treatment, usually after 2-4 weeks.
The introduction of maximum therapeutic doses of drugs involves the development of side effects of varying degrees. They can be observed directly (nausea, vomiting, allergic reactions, etc.), at the earliest date (leukopenia, thrombocytopenia, diarrhea, stomatitis, etc.) or in the long-term period as a result of prolonged use of drugs (nephro-, cardio-, neuro -, ototoxicity, etc.). Side effects are carefully recorded, which is important in the planning of further chemotherapy.
Chemotherapy, known as targeted treatment, is inherently a medical treatment of cancer. Drugs used in this case belong to the category of so-called "smart" drugs.
The difference between classical chemotherapy and targeted chemotherapy is that "smart" drugs can clearly identify mutating cells and exert a destructive effect exclusively within the malignant neoplasm, without affecting healthy organs and tissues. These drugs are less toxic than classical drugs that are used in chemotherapy. Therefore, they can be used in those cases when the other drugs are contraindicated for the extremely malnourished by cancer patient.
Treatment of cancer with the help of modified drugs of the target therapy is successfully carried out in Turkey.
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